Basepaws Health Report: List of Genetic Conditions and Traits

Basepaws has added new genetic health and trait markers to its flagship Breed + Health Cat DNA test. In the Health Marker section of your cat’s report, Basepaws provides their results related to 43 genetic disorders that are represented by 64 health markers. Mutations in different genes are associated with a higher likelihood of developing certain diseases or exhibiting specific traits. A genetic marker is the precise gene sequence change associated with a trait or a disease.

The complete list of genetic disorders currently included in the Health Marker section of the Basepaws report includes the following:

Metabolic disorders:

1. Mucopolysaccharidosis I
2. Mucopolysaccharidosis VI
3. Mucopolysaccharidosis VII
4. Neuronal Ceroid Lipofuscinosis (NCL)
5. Porphyria, acute intermittent (AIP)
6. Porphyria, congenital erythropoietic (CEP)
7. Alpha-mannosidosis
8. Niemann-Pick disease, type A
9. Niemann-Pick disease, type C1
10. Niemann-Pick disease, type C2
11. Gangliosidosis, type GM2 (variant 0)
12. Gangliosidosis, type GM1
13. Gangliosidosis, type GM2 (variant AB)
14. Wilson's Disease
15. Dihydropyrimidinuria
16. Pyruvate Kinase (PK) Deficiency
17. Hyperlipoproteinaemia

Musculoskeletal and connective tissue disorders:

1. Hypokalemic periodic paralysis (HYPP)
2. Vitamin D-deficiency rickets, type IA
3. Vitamin D-deficiency rickets, type IB
4. Myotonia Congenita
5. Ehlers-Danlos Syndrome (classic type)
6. Fibrodysplasia Ossificans

Renal disorders:

1. Cystinuria, type B
2. Cystinuria, type IA
3. Polycystic Kidney Disease (PKD)
4. Primary Hyperoxaluria, type II (Oxalosis II)

Cardiovascular disorders:

1. Hypertrophic Cardiomyopathy (HCM)

Blood disorders:

1. Factor XII deficiency
2. Methemoglobinemia
3. Haemophilia B
4. Glanzmann Thrombasthenia

Eye disorders:

1. Glaucoma, primary congenital
2. Progressive Retinal Atrophy (AIPL1-related)
3. Late-Onset Photoreceptor Degeneration (rdAc)
4. Progressive Retinal Atrophy (KIF3B-related)

Endocrine disorders:

1. Congenital Adrenal Hyperplasia (CAH)
2. Hypogonadotropic Hypogonadism, congenital (TAC3-related)
3. Hypothyroidism, congenital

Skin disorders: 

1. Inflammatory Linear Verrucous Epidermal Nevus (ILVEN)
2. Epidermolysis Bullosa Simplex

Autoimmune disorders:

1. Leukocyte Adhesion Deficiency (LAD)
2. Autoimmune Lymphoproliferative Syndrome (ALPS)

The Basepaws Breed + Health Cat DNA test also screens for 25 genetic traits that are represented by 50 genetic markers.

In addition to learning about the genes responsible for your cat’s unique physical appearance, you will receive results for your cat’s blood type and their likelihood of having some genetically conferred resistance to the Feline Immunodeficiency Virus (FIV).

The full list of genetic traits is included below:

1. Blood type
2. Albinism
3. Amber coat color
4. Russet coat color
5. Black coat color (melanism)
6. Blotched tabby coat pattern
7. Mackerel tabby coat pattern
8. Burmese coat color
9. Siamese coat color (pointed)
10. Charcoal coat color
11. Chocolate (dark brown) coat color
12. Cinnamon (light brown) coat color
13. Copal coat color
14. Dilute coat color
15. Curly coat (KRT71-related)
16. Curly coat (LPAR6-related)
17. Hypotrichosis (with short life expectancy)
18. Long-haired coat
19. Lykoi coat
20. Osteochondrodysplasia and folded ears
21. Polydactyly
22. Short and kinked tail
23. Short tail
24. Sphynx coat
25. Likely resistance to FIV

Basepaws will continue to make periodic updates to its genetic health and traits marker panel. These updates will come from both Basepaws’ internal research, as well as other sources of feline genetic research. If you have any questions about your cat’s report, you can email us at meow@basepaws.com.

More about your Basepaws Cat DNA Report:

1. Understanding your cat's report
2. List of Breeds
6. Chromosome Map